What Causes Post-Injection Pain?

The following article was written by user ‘one8nine’ of Steroid.com forums

First We’ll Talk About Esters

Ester – An ester is a chemical modification were a alkyl group or groups are added to increase circulating time of a steroid compound, which controls the release of the hormone into the blood. The first word in the chemical name is the hormone, and the second word is the ester attached to the hormone; for example in Testosterone Enanthate the hormone is “Testosterone ” and the ester is “Enanthate ”. The only difference between Testosterone Enanthate, Testosterone Decanoate and Testosterone Propionate is the rate of release of the hormone into the blood stream.

Short ester – breaks down more quickly, requires EOD or ED injections. Examples are acetate and propionate

Long ester – allows for a slower break down, therefore 2XW injections. Examples are Enanthate and Decanoate.

17AA – Changing (Alpha Alkalizing) a hormone’s seventeenth position from carbon to a double hydrogen (C -> H2). Also known as “Methyl”. This process protects the hormone through the first pass in the liver, allowing a usable amount of hormone to be left over. Examples are M1T (Methyl-1-Test) and M-Tren (Metrienolone)

Suspension – A non-esterfied hormone (Testosterone, no ester) or a 17aa that is “suspended” in a liquid solution to be injected or swallowed. More commonly water based but can also be found oil based. The most common example is injectable Winstrol. Very painful due to fast release and also ED or 2XD injections are necessary. The only real advantages to using suspensions are the quick rates at which they enter the blood and are released from the blood, great for controlling exact levels and avoiding testing.

What Causes (Non Infection Related) Injection Pain?

  • 1st – The shorter ester, the higher the melting point
  • 2nd – The concentration of the gear
  • 3rd – The solvents used
  • 4th – Injecting too quickly
  • 5th – Virgin muscle

Pain is caused when oil/solvents are absorbed by the body and crystals are left behind.

Short esters (propionate or acetate) are harder, more painful crystals with melting points in the 100c range.

A hormone with longer esters (excluding cypionate – cyp is long but also high melting point) can have a melting point in the 20c – 40c rang. Not far off from the human body temp.

Pain Is Also Caused by Concentration of Gear

Building off of 1: Let’s say it takes the body 24 hours to absorb 1mL of a certain oil/solvent blend, and 24 hours to absorb 50mg of Testosterone Propionate. If 50mg (or less) of testosterone propionate is in 1mL of that oil, this injection should be painless. On the other hand, if 100mg of testosterone propionate is in that same 1mL of solution, then after 24 hours the body will have absorbed 50mg and 1mL, leaving 50mg behind in the injection area, crystallized and painful.

It is better to shoot 3mL of 50mg/mL Testosterone Propionate than 1mL of 150mg/ML Testosterone Propionate.

This is why water based suspensions (Testosterone base/no ester, Winstrol) hurt the most, water is very easily absorbed in the body.

The solvents used can cause pain in two ways:

Benzyl alcohol (BA) is used at 1% – 2% as a preservative and antiseptic. If the alcohol content is too high the gear will burn. Pain in the first 24 hours is usually caused by heavy solvents, pain in the next few hours is caused by crystallization.

Another Way Is a Bad Recipe

If someone used 2% BA, and the rest of the solution oil, the mg/mL would have to be low due to oil’s weak ability to hold crystals. On the other hand, a recipe like 2% BA, 5% Guaiacol (super solvent), 10% BenzylSalicylate (liquid aspirin) with the filler split 50:50 between Ethyl Oleate (oil/solvent hybrid) and normal oil should be far less painful.

Pain is also caused if you inject too quickly, it can tear tissue.

If your muscle is new to the hormone, it will absorb the hormone very slowly, but absorb the oil/solvent very quickly. This will cause more crystallization and pain. As your muscle recognizes the hormones, they will be absorbed more quickly thus less pain. The deeper you inject into the center of a muscle group, the better.

How Do I Prevent Pain Before I Inject?

This is the #1 best way. Cut your shots into 50:50 with sterile filtered oil. If you want to use 50mg of Testosterone Propionate, and you have 100mg/mL Testosterone Propionate pull 0.5mL of your test prop, and 0.5mL of sterile filtered oil to shoot 1mL of 50mg/mL Testosterone Propionate. Don’t bother with B-12 it is water based – absorbed so quickly it will have little to no impact. if you can’t access sterile oil use something like Mast P, Mast, Deca, Test C etc. to cut the concentration down.

Before you shoot, it can help to warm your gear some (especially suspensions). You could put the vial in the bathroom sink and let hot water run over the vial for 2 minutes, and shake well. This will lower the oils viscosity also making it easier to pull into the syringe.

Inject slowly, take 30 seconds per mL. Use a 25g pin to inject so it forces you to move slowly.

How Do I Deal with the Pain Once I Have It?

The worst thing you can do is ice it. Cold will help the crystals fall out of the solution/suspension. It is okay to take some ibuprofen to decrease the swelling, and help with the pain.

Also being in a hot tub, or Jacuzzi, or warm bubble bath will help melt the crystals down. Using a heating pad can help also.

4 Responses

  1. […] For a first cycle I recommend glutes only, a nice big muscle with decent circulation and low risk of hitting any nerve clusters. The twisting and turning can be a problem for some in which case I’d advise shooting quads but there is a slightly larger margin for error in regard to hitting nerve clusters and puncturing large veins. An article regarding post-injection pain and how to avoid it can be found here. […]


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