Metribolone (Methyltrienolone) Reviews

The following information was taken from r/steroids Compound Experience Saturday post for M-Tren

Metribolone (Methyltrienolone)

Methyltrienolone is one of the strongest oral anabolic steroids ever produced. This agent is a derivative of Trenbolone (Trienolone), which has been c-17 alpha alkylated to allow for oral administration.This modification has created a steroid that is significantly stronger than its non-methylated cousin. Its potency has been measured to be anywhere from 120-300 times greater than that of Methyltestosterone, with greater dissociation between anabolic and androgenic effects.625 626 Milligram for milligram Methyltrienolone is a more active steroid than any agent sold on the commercial market, requiring doses as little as .5-1 milligram per day to notice a strong anabolic effect. Its potency is only matched by its relative toxicity, however, which has limited its modern use to that of laboratory research only.

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History

Methyltrienolone was first described in 1965.627 It was immediately identified as an extremely potent anabolic agent, far more potent than the commercially available agents of the time. In spite of its high relative activity, however, methyltrienolone has seen very limited use in humans. It was used clinically during the late 1960’s and early ’70’s, most notably in the treatment of advanced breast cancer. Here, its exceedingly strong anabolic/androgenic action helps the drug counter the local effects of endogenous estrogens, lending it some efficacy for slowing or even regressing tumor growth. Such application was not long lived, however, as more realistic evaluations of the drug’s toxicity soon led to its abandonment in human medicine. By the mid-1970’s, methyltrienolone was becoming an accepted standard in non-human research studies, particularly those pertaining to the study of the androgen receptor activity. For this purpose the agent is very well suited. Its sheer potency and resistance to serum-binding proteins makes it an excellent in-vitro receptor-binding standard to compare other agents to. Being so resistant to metabolism, active methyltrienolone metabolites are also not going to greatly interfere with the results of most experiments. Body tissues can metabolize most steroids fairly easily, which means that even incubation studies can be complicated with the question of what is causing a particular effect, the steroid or one of its unidentified metabolites. This is much less of an issue with methyltrienolone. Today, methyltrienolone remains an agent of research use only.

Structural Characteristics

Methyltrienolone is a modified form of nandrolone. It differs by: 1) the addition of a methyl group at carbon 17alpha to protect the hormone during oral administration and 2) the introduction of double bonds at carbons 9 and 11, which increases its binding affinity and slows its metabolism. The resulting steroid is significantly more potent than its nandrolone base, and displays a much longer half-life and lower affinity for serum-binding proteins in comparison. Methyltrienolone chemically differs from trenbolone only by the addition of a methyl group at c-17. This alteration changes the activity of methyltrienolone considerably, however, such that this agent should not simply be considered an oral form of trenbolone.

Administration

Studies have shown that taking an oral anabolic steroid with food may decrease its bioavailability.630 This is caused by the fat-soluble nature of steroid hormones, which can allow some of the drug to dissolve with undigested dietary fat, reducing its absorption from the gastrointestinal tract. For maximum utilization, methyltrienolone should be taken on an empty stomach.

Methyltrienolone is no longer used in clinical medicine due to an unacceptable level of hepatotoxicity.This agent is generally not recommended for physique-or Performance-enhancing purposes for the same reason. Those absolutely insisting on its use need to take its level of liver toxicity very seriously. At the very least, routine blood tests should be conducted to ensure the agent is not imparting damage. Drug duration should also be very limited, preferably to 4 weeks of use or less. The relative potency of methyltrienolone is extremely high, requiring doses as little as .5 milligram per day. Its effective and tolerable range is usually considered to be .5 to 2mg per day. Dianabol-type doses of 20-30 mg daily are completely unthinkable, and should never be attempted. Again, this is an extremely toxic steroid, and all good advice would say to avoid it. Anyone of the many commercially available steroids would be much safer choices.

Reviews

TheJungernaut:
I ran 750mcg upon awakening and 750mcg pre-workout for 4 weeks on / 2 weeks off / 4 weeks on. Some days I added another 750mcg at lunchtime. Grew like a fucking weed. No liver support. Heptatoxicity is overblown in my experience. No jaundice or liver pain or lethargy. Slightly elevated ALS / ALT — not enough to concern doc.

Jcaesar369:
I have used Mtren in an injectable pre-workout blend at 500 mcg. This is an oil based blend sometimes referred to as C4 (like dynamite…hardy har har) and contains 100 mg TNE, 50 mg tren no ester, 1 mg mtren, and 500 mcg mibolerone per 1 ml. I have only ever taken 0.5 ml 30 mins before working out. I have taken TNE and tren no ester both together and separately before, so I know the difference between them and the mtren and mibolerone.

To focus on the mtren: gives great instant tren like strength. It almost feels like anti-gravity. All the weights in the gym are just lighter. Makes you very hot and sweaty, and makes me very very hungry after an hour or so. Intra workout carbs or a bigger pre-meal would be a good idea. This really was the worst side effect for me, I did not take any TUDCA nor experience any liver lethargy, but I have only ever done 500 mcg at once, and only up to 3 days in a row. The injectable version is also slightly easier on the liver due to bypassing first pass metabolism, so if you are wary or concerned for this factor, I will always recommend you inject any methylated or liver toxic roid if you can safely.

For a weight comparison: on mtren I can shrug 4+ plates on each side of the hammer strength shrug machine for 8-12 reps for 3-4 sets. On my normal blast right now of 500 mg test E, 600 mg DHB, and 350 mg mast prop per week I can only shrug 4 plates for 8 reps for about 2 sets. The strength truly is incredible.

Gives very very nice juicy pumps and big bulging veins. Great for squatting or deadlifting big weight with ease. I would highly recommend mtren to anyone looking to greatly enhance their workout, lift heavier weights (hint hint powerlifters), or just look like a gnarly grainy shredded freak in the gym and in life.

Aside: I am fairly (99%) positive that my strength and the sides discussed above are from the mtren and not mibolerone in the PWO blend. I think the mibolerone gave incredible aggression and focus, but that is a topic for another Saturday 😉

On the topic of stronger roids: I know they are hyped up to be scary or extremely liver toxic or dangerous or not for the light of heart, but they really are where the magic of steroids starts to shine.

Look at sdrol and tren. Both give you an incredible look. The even stronger roids like M1T, halo, mtren etc are going to be just as incredible, if not more so. I have found that by trying sdrol and M1T that they are very fun to run and use and make you look swole as hell. If you are interested in trying new compounds I really truly do recommend it just for the sake of trying and experiencing new things.

MaintenanceOfPeace:
Used it at 400mcg pre workout this week on my bench day and basically felt like doubling my current tren dose from 600mg a week to 1200mg a week. It was a spur of the moment usage but I’ll probably be using it to keep strength up when I cut later in this blast, I can update then, I’ll need to get more tudca when that time comes, however. Thinking of 200-400mcg pre workout until my 200mcg x 50ml bottle is gone (oral).

cfthrowaway948:
Ran 2mg a day orally for a few weeks before I started to lose my appetite and came off.

Strength gains slightly better than 30mg Sdrol.

Insane recompositioning effect. I was eating milk and McDonalds just dirty bulking and I still got leaner.

Focus in the gym felt similar to a low dose of amphetamine. Max on all lifts instantly went up 10-30lbs, felt no desire to rest between sets, and my subjective sense of work capacity about doubled. Really felt like a machine.

Vascularity better than Tren + Mast, pumps just under those of Sdrol.

In the short time I was on it I think I added about 100lbs to my total.

I wasn’t taking any liver support or drinking very much water. I feel like I could handle 500mcg or so a day for a pretty extended period of time. I think it’s hepatotoxicity is really overstated, as are most orals.

All in all spectacular oral. I still prefer Superdrol though.

Allnattybra:
I used oral mtren at 2 mg for 2 weeks then 1 mg for 2 more weeks. developed no signs of jaundice, lethargy, or appetite loss.

experienced out of breath symptoms similar to 700 mg tren. the pumps are hard to compare to tren because i was also running test/nandrolone. but, by far the vascularity and drying effect were more pronounced, in my opinion. cheeks sunk in and deltoid separation were what people complimented me on during the run. the vascularity was better than when i ran anavar and winstrol. this drug seems to be the best for recomposition effects. i was able to eat ridiculous amounts of carbs only for my muscles to fill up and waist even got tighter. for fear of deleterious sides, i stopped the run at 4 weeks but really felt i could’ve ran it longer. interested to see why this is the case; perhaps the low dosing of mtren actually makes it less hepatotoxic than what has been notoriously spouted. at any rate, i feel that this drug has great potential pre contest and as a plateau breaker for those who need it. i do not recommend it at all for those who are sensitive to the highly androgenic nature of the compound. the accelerated hair growth around my back/chest is a bother. fortunately, i am not predisposed to MPB so i cannot comment on this.

BasicGymBro:
Ran 500mcg and 1mg PWO for four weeks while cutting on cruise. Best benefit was lasting intensity and zoning. Every workout I go through a bit of a ritual beforehand to kind of flip a mental switch. I’m fairly quiet and very calm under normal circumstances; the more years of lifting I put behind me the easier it is to flip that switch. Consciously drop any care I have for people’s opinions of me. Preworkout makes this easier, inhaled amphetamines more so. Try and become the fucking douche I look like but am really not. Stacked with cannibal ferox (never lifted without it during that month), mtren completely flipped that metaphorical switch the second I started my little ritual. Turned my workouts up to 11, big strength gains and a manic energy to make every muscle HURT. May be hyping it a bit, but I definitely had more utterly insane workouts in that month than any other aggregate year. Definitely looking to run it again once Im done with accutane.

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