The following information was taken from r/steroids Compound Experience Saturday post for Primobolan
17 beta-hydroxy-1-methyl-5 alpha-androst-1-en-3-one
Molecular Weight of Base
Molecular Weight of Acetate Ester (Oral)
Molecular Weight of Enanthate Ester (Injectable)
Active Life of Oral
Active Life of Injectable
Anabolic/Androgenic Ratio (Range)
Primobolan is one of the unique compounds that can be administered either orally or by injection. The only difference in the compounds is the ester attached, the oral version using acetate and the injectable version using enanthate. However regardless of the method of administration or ester used methenolone is considered by most to be a relatively mild compound. For the most part users should not expect to make major gains in muscle mass from this drug but rather lean gains in muscular body weight.
In some animal studies it has been demonstrated that methenolone has the potential to increase muscular size and strength. However the anecdotal evidence from users suggest that any mass gains using the compound will not be overly significant. However it has been noted as quite an effective “cutting” drug because of it’s ability to bind to the androgen receptors in the body. Of course the ability to bind to androgen receptors has been shown to promote fat burning in individuals. This effect would obviously be highly desirable during “cutting” phases or to simply limit the amount of body fat one puts on during a bulking phase.
Promonolan does not convert to estrogen and therefore estrogenic side effects should not be a concern with this compound. As well, unlike other oral anabolic steroids it is not 17 alpha alkylated. This means that it is far less stressful to the liver than other oral steroids. However the process that oral methenolone does go through to make it orally active, 1 alkylation and 17-beta esterification, does not protect it during the first pass through the liver very well at all. This requires that the oral version of methenolone must be run at higher doses than would be expected with the injectable version. For this reason it is often said that the injectable version of the drug is far more efficient at producing gains.
In terms of therapeutic/medical use of methenolone, it has been argued by some researchers that it has shown some ability to promote immune system function in AIDS patients. This is different than the anti-muscle wasting properties that some anabolic steroids are used for. In several studies it’s been demonstrated that methenolone does not exhibit this capability. However in terms of enhancing immune function this could be attributed to the increased nitrogen retention that methenolone promotes. While this effect alone won’t prevent muscle wasting in those suffering from AIDS, it can help to maintain muscle mass in less severe circumstances, such as calorie restricted diets. But despite these advantages methenolone is not approved for any type of medical use in North America.
The difference in the dosing that is required for the oral and injectable versions of methenolone, as described earlier, is due to the action of the liver and the fact that the majority of the oral compound will not make it to circulation in the body. Also, due to the differing esters/structures of the compounds the frequency with which a user must administer them is also different. The oral form of methenolone should be administered at least once per day to maintain consistent blood levels of the drug, while the active life of the injectable version of the drug is such that administering it once per week is possible because of the enanthate ester, although splitting the doses to twice per week would provide much more consistent blood levels of the drug.
For the oral version of the compound to be effective most male users of methenolone will need to administer roughly 80 to 150 milligrams per day. This demonstrates truly how much of the drug does not make it past the liver intact. Compare it to the 200 to 400 milligrams per week many users anecdotally report they administer of the injectable version and have good results with. Of course many users will increase dosages beyond these with amounts ranging from 600 to 800 milligrams per week or higher of the injectable compound not being uncommon.
For women that are inexperienced with methenolone doses of the oral version of the drug have anecdotally reported ranging from about 40 to 75 milligrams per day. For the injectable, 50 to 150 milligrams per week should produce very noticeable gains in muscle mass and quality. At these dosages very little in the way of virilizing effects should be experienced by the majority of female users. However as dosages are increased, so is the likelihood that these effects will become evident.
As for the length of time that methenolone can be run, due to the lack of toxicity issues associated with the compound and the relatively mild nature of it in terms of side effects there is little to worry about even if using it for weeks at a time. Liver, kidney or other organ damage should not be a concern for healthy individuals. Suppression of natural testosterone production in males does of course occur, but only the usual protocol of post-cycle therapy is needed to regain this.
Female users have reported that methenolone is quite effective if run alone, however some will stack it with other compounds for an extra anabolic effect. Male users will rarely run methenolone by itself, instead choosing to add it with any number of other potential compounds. This is primarily due to the mild nature of the drug. Used in conjunction with other drugs it can offer several benefits, but alone it will likely leave the user unsatisfied. However anecdotally users report that if used in combination with other compounds it can be effective in “cutting” or “bulking” phases. This is despite the fact that methenolone itself will not result in major gains in muscle mass. It does however help and is quite effective at preserving muscle mass while dieting as well as enhancing the appearance of a user’s muscles.
For the most part, side effects are almost non-existent with methenolone. However due to it being a DHT derived steroid prostate problems and the exacerbation hair loss if a user is prone to male pattern baldness can occur for users of the compound. Many will use ketoconazole and/or finasteride to help with these effects.
Due to the fact that methenolone does not aromatize, estrogenic side effects are of no concern with this compound. This is another reason why it is often utilized by bodybuilders during their pre-contest preparations. Water retention, gynecomastia, and a rise in blood pressure should not occur from use of methenolone. Due to this, there is no need for anti-estrogen or anti-aromatase compounds while cycling this drug. In fact, there is some evidence that methenolone can act as an anti-estrogen itself, much in the same way that drostanolone does. However this effect is weak and should not be relied up for these purposes.
In terms of organ toxicity, methenolone shows no signs that it is capable of causing organ damage in healthy individuals, even at relatively heavy doses. If dosages are kept within reason, there should be little in the way of concern about possible organ damage while using methenolone.
The same can be said for virilizing effects in women. While such things are deepening of the voice, menstrual irregularity, and body/facial hair growth, among others, are definitely possible, they should be minimized if female users do not use the drug to excess. These effects are of course permanent if they do manifest themselves.
Primo stacked with test is a nice combo. Low (i.e., zero) sides, good overall feel, not a spectacular mass gainer but that’s not really what it’s for. Only downside is it’s usually dosed 100mg/ml and let’s call it “around $100” a vial so makes for an expensive addition. Shit I just realized I’m spending “about $50” a week on the stuff right now. Speaking of which 500mg is a good dose… But I have a feeling one could run grams of this stuff if they could afford it. I think it’s given me the least sides of all the major steroids.
Have run it: 250 test and 200 primo (as a cruise), 500 test 500 primo 50mg Var (the champagne stack… Way too expensive for what I got out of it), and now 750 test / 500 primo / 500 tren a / 500 mast prop (prepping for a show).
I’m currently on 600 primo / 300 test. I’ve run primo at 300/wk on a cruise and up to 900/wk with 500 test and 600 mast.
I love primo. It’s a slow quality builder with no sides at all. I notice increased recovery and quality mass built over a longer period of time. It’s expensive, but as a very busy professional with a wife and two kids, I can’t afford the side effects of tren and I like the fact that primo is a dry compound – unlike deca.
I’m currently running 150/350/50/10 test/primo/proviron/MHN, week 9 starts monday.
I’m not the most experienced user on here, but I’ve got a few cycles under my belt
I keep my test low because I’m really susceptible to gyno and most AI’s give me mood swings. I took letro to get rid of some from my last cycle and that was not fun. Proviron is mild enough to not fuck with me, but provides some support
I really like primo. Like other users have said, there’s basically no sides. I train powerlifting, so I’d rather take compounds that aren’t going to add much weight. For that purpose primo has done a great job. I’ve had steady, predictable progress on a linear progression type program that I wrote for myself. For the first 5 weeks I ran var at 50mg/day. I could feel a little slow down when I got off it. I took a few weeks to give my liver a break, now I’m less than a week into MHN. Still at the 10mg/ day dose before I ramp up. I could feel a boost by the 3rd day, and my vascularity has came back quick.
Primo is helping me push toward my specific goals, but I don’t see this serving much a purpose to a bodybuilder because of the price. I should also add that I bought mine at 50% from the shelf price otherwise I may not have paid for it. Same with the var. On one hand though, I am willing to pay a little more and take a little longer to reach my goals if I can save myself from shitty side effects.
Ran oral primo ace to try it out. Was actually a better deal than pinning enanthate, pinning ace would have been cheaper but I didn’t want to deal with ED pins at the time.
Definitely good recovery and a good feeling from the primo. Started at 100 mg ED spaced out and upped eventually to 150 and 200 mg per day. 200 mg gave me bad night sweats immediately and 150 did as well after a few days so I dropped back to 100 mg ED.
I will say it brought out the delta and traps similar to tren but the vascularity is not equivalent at all. Primo feels more similar to mast for me but not as horny or great libido or super hard boners. Seems to build a bit more mass than mast tho.
All in all not worth the money for me, if you want bigger gains there are better roids out there.
I’m 4 weeks in on 300 primo e 375 test e 500 mast e 50mg var and I noticed about the same strength, endurance and size from 300 npp than 300 primo. Muscles do look nicer and fat loss has been great but that could be the HGH/Carnitine/Cardio/Clen.
I’d say its only worth it if you really have money to burn and are running high doses. like you cant really run a gram of npp or tren without feeling gross, but people run that much Primo without too many sides and great results.
It’s about 2.5x the price of NPP so its not really worth it at my level. for an advanced guy willing to spend at least 100 a week on just injectables, and sensitive to sides, it could make sense.
Currently on week 8 of
- 1-20 test e 750, primo 900
- 1-6 dbol 60mg/d
- 5-20 tren e 400mg
- 16-20 sdrol 30mg/d
- 1-52 5iu GH/d
I have my primo dosed at 150mg/ml, so pin my 6ml in 3x2mL doses. That way I can do 2cc primo and 1cc test (250mg/ml) and most muscle groups take 3cc at my size.
I’m (obviously) bulking. TDEE is 3800 and I’m eating 4200 calories. Really starting to notice the primo now. Long ester, and it’s hard to pin (150 is much harder than 100mg/ml) but well worth it. For it’s cost…next time I’ll go back to tried and true deca. Even dosing deca at 1.2g you’ll get a lot more bang for your buck than primo. However, primo is a DHT and synergizes nicely with the tren. What I’m really testing is if it’s a suitable replacement for mast as I find mast nearly worthless. I mentioned above I’d rather deca…well I don’t use deca into a competition. So for bulks I’d take deca (cost and greater anabolism) whereas for competitions..test/tren + primo or mast will be the go.
No sides, which is great. May use it again, this remains to be seen until another 5-6 weeks before tren is in full swing. Never used the ace or pp esters.