The following article was written by SoulSearcher from UK-Muscle
Background and history of 1,3 DMAA
1,3 DMAA is a simple aliphatic (repeated pattern) amine. 1,3 DMAA was first isolated and patented in 1944 by Eli Lily, and trademarked in 1971 as Forthane for use in a nasal decongestant. Under USA law the patent has now expired and was re-investigated as a dietary supplement in 2005/2006 following the banning of Ephedrine. It was initially introduced as Geranamine (as it was originally derived from Geranium stems, although most 1,3 DMAA is now synthesised and is FDA approved) and the trademark for the name Geranamine was granted in 2006.
As well as the benefits for weight loss, because of its similarities to both Ephedrine and Amphetamines, 1,3 DMAA is finding its way in to party pills, although at the doses being used by people there are reports of nausea and headaches.
1,3 DMAA was banned by the World Anti-Doping Agency in 2009, and there have been a number of high-profile cases since resulting in international bans being given.
How does it work?
Despite 1,3 DMAA being chemically different, it has a very similar action to Ephedrine and effects the release of norepinephrine at a cellular level. Also like ephedrine the principal mechanism of its action relies on its indirect stimulation of the adrenergic receptor system, by increasing the activity of noradrenaline at the post-synaptic alpha and beta receptors. These actions increase the metabolism of fats from adipose tissue, and also may prevent new fat being deposited.
!,3 DMAA will downregulate the receptors in your cells, therefore will need to be cycled. I would imaging that 4 weeks on and 4 weeks off will give maximum benefits, although longer on-cycles may be possible. I will know more once I have concluded the practical part of my research.
1,3 DMAA is widely available as an addition to a large number of fat-burning products right now.
Like ECA and Yohimbine, it does increase neurological activity and anxiety and so should be avoided by people with any anxiety issues, any history of mental problems or family history of mental problems. Also given that 1,3 DMAA effectively raises the levels of norepinephrine then taking it too late at night can cause insomnia, although from personal experience this seems to be much less extreme than Yohimbine and certainly ECA.
There have been two cases of stroke associated with 1,3 DMAA, one a man of 21 after taking 1,3DMAA (99.9% purity in party pills), caffeine and booze, and a 45 year old man of whom no further details are known.
Additionally as with all central nervous stimulants, 1,3 DMAA should NOT be taken by those people how have any history of, but not limited to, strokes, high blood pressure, heart, liver, kidney, or thyroid disease, diabetes or anemia, a family history of these or other medical conditions, or if taking any prescription, OTC, and/or other herbal medications. Please consult with a qualified medical practitioner if in doubt.
25-50mg is a common dosage for DMAA. The old JACK3D pre-workout supplement had 20mg per scoop and taking 2 scoops was common practice. It is best to assess how well you tolerate DMAA by using a small dose of around 20mg initially and slowly tapering up as time goes on. A study in which 75mg servings of DMAA were used presented issues with large spikes in blood pressure.
This product is probably more widely available and easier to come by than ECA, Yohimbine and Rauwolscine. However there is some on-line controversy around those products that list Geranium Stem on their ingredient list, as dependent upon species there may be only 0.06% – 1% 1,3 DMAA present, and therefore efficacy may be questionable.
I use firstname.lastname@example.org – they stock DMAA and a range of other stimulants. Shipping to the UK usually takes 1-2 days and they do ship internationally too. Just send them an email explaining that you got their email address from this website and ask for a price list and they will send over a full list of products and prices.