Bodybuilder’s Yohimbine Fat-Loss Guide

The following article was written by SoulSearcher from UK-Muscle

Background to Yohimbine

Yohimbine is an indole alkaloid with stimulant and aphrodisiac effects found naturally in Yohimbe (Pausinystalia Yohimbe). It is also found naturally in Indian Snakeroot (Rauwolfia serpentina) , along with several other active alkaloids. Demand for Yohimbine internationally has led to a dramatic decrease in the plant’s population, such that in some areas it is now threatened with extinction.

Yohimbine is used as both an over-the-counter dietary supplement in herbal extract form and prescription medicine in pure form for the treatment of sexual dysfunction. It used within veterinary medicine in injectable form, under the trade name Antagonil, as a reversal agent for Xylazine anaesthesia.

Yohombine has also been looked at as a possible treatment for type 2 diabetes.


How does it work?

Yohimbine blocks the pre- and post-synaptic alpha-2 adrenoceptors, this prevents the release of Norepinephrine from cells. Norepinepherine stimulates both the alpha and beta receptors in a cell. Stimulation of the beta adrenoceptors causes the breakdown of fat, whilst stimulating the alpha-2 adrenoceptors prevents this breakdown of fats. Yohimbine blocks the alpha feedback mechanism, thus increasing norepinephrine and fat breakdown.

Like Ephedrine it does not act directly on the Beta receptors, and therefore does not need to be cycled in the same way as Clenbuterol does, there is more information on this below.

Additionally blocking the post-synaptic alpha-2 adrenoceptors leads to minor corpora cavernosa smooth muscle relaxation. In fact the majority of adrenoceptors in the corpora cavernosa are alpha-1. These are the properties of Yohimbine and Rauwolscine that mean it is useful in the treatment of erectile disfunction. This may prove useful for those in bodybuilding who are using, or have recently stopped using AASs, as loss of libido and erectile problems are a known side effect of these substances.

It should be noted that the the abdominal area in men and the glutofemoral (butt) area in women contains a higher ratio of alpha-2 receptors, this could make Yohimbine more effective in these areas. Also blocking the alpha-2 receptors increases blood flow in fatty tissue, which also may prevent fat from being retained or deposited in the area.


Yohimbine is available as a direct alkaloid extract from the plant, normally illustrated as a percentage. This is indicative of the amount of Yohimbine present within the alkaloid spectrum of the plant used, and is typically 10-15%. It is also available in a more potent form as Yohimbine Hydrochloride (Yohimbine HCL). Yohimbine HCL is a safer route to take as some of the other alkaloids present in the herbal extracts may have toxic side-effects, and the HCL variant also gives a more consistent dosing profile.

Side Effects

As with ECA, anxiety and panic attacks are the most common sides, as well as minor (non-visible) shakes and some people report increased heart rate. Also those people who have any issues around blood pressure should also keep a close eye on thsi whilst using Yohimbine. Also given that Yohimbine effectively raises the levels of norepinephrine then taking it too late at night can cause insomnia, although from personal experience this seems to be much less extreme than ECA.

Yohimbine should NOT be taken by those people how have any history of, but not limited to, strokes, high blood pressure, heart, liver, kidney, or thyroid disease, diabetes, anemia, depression, anxiety, other psychiatric conditions, a family history of these or other medical conditions, or if taking any prescription, OTC, and/or other herbal medications.

Taking Yohimbine HCL

The general consensus is that a dose of .2 mg/kg (approximately 1 mg per 11 lbs.) per day is relatively free of side effects and effective for weight loss, so if you weigh in at 100KG then a daily dose of 20mgs will be ideal. For best results the Yohimbine dose should be taken twice a day, early morning and early afternoon. It is best taken on an empty stomach, and before any cardio. As with all substances that have a direct effect on receptors it is advisable to start ff on a lower dose to assess individual tolerance to the substance. As has been mentioned individuals may react differently to its insomnia properties, so take care if taken later in the day. There is some evidence that Yohimbine acts synergistically with caffeine for fat loss through PDE inhibition. Whether use as a Yohimbine-Caffeine-Aspirin stack yields the same benefits as the ECA stack has yet to be studied. Although as a foot note My next Yohimbine cycle will try this as a possibility. I will report any findings back here as an update to this article.

I normally take Yohimbine 4 weeks on and 4 weeks off, very often between ECA cycles.

It is also worth noting that L-arginine and other Nitric Oxide enhancers may operate synergistically with Yohimbine as a sexual stimulant.

A possible synergism between yohimbine and ephedrine hasn’t been thoroughly explored, and the information that exists is somewhat contradictory. I have not used Yohimbine at the same time as Ephedrine so can add no further personal information to this.

Products and Suppliers for Yohimbine HCL

Yohimbine is also available as a topical preparation under the names Eviscerate from RPN and Napalm from Avant. There are people that have claimed that these work in reducing the fat in the areas they are applied, again I have no experience with these products.

Finally it is also available as a human injectable form called Helios, which also contains Clenbuterol. It was made by the UGL Generic Supplements, but again can offer no further information at this point on the product.

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