The following information was taken from an article written by KB from Evolutionary.org
Molecular Formula: C46H56N12O6
Molecular Weight: 873.01
CAS Registry Number: 87616
There are two separate categories of growth hormone peptides, these two categories fall into what we call GHRH (growth hormone releasing hormones) and GHRP (growth hormone releasing peptides). GHRH will increase the amount of growth hormone that can be secreted at the body’s natural timing, and GHRP will target a pulse that forces the pituitary to secrete growth hormone that you have stored. In this article we will be focusing on a specific GHRP named GHRP-6 (Growth hormone releasing hexapeptide).
As we get older, we do not stop producing growth hormone (GH), but, in fact, we just do not produce as much as we did when we were growing up. The male body has selected times during the day when the body is ready to release some of the stored growth hormone. Interestingly, the most powerful GH release comes when we sleep (this is why it is important to sleep like a baby). If you are concerned with building muscle, then you know that sleeping and eating are two of the most important factors that you need to keep growing.
Hunger and Ghrelin
Food intake is where GHRP-6 is going to outshine other GHRP peptides. This is mainly due to the fact that GHRP-6 is known to drastically increase hunger, which normally occurs within an hour after injection. The extreme hunger has been linked to the increase of Ghrelin within the stomach. Ghrelin is a hormone that is produced by cells in the stomach that are released due to the stomach being empty or if the stomach thinks it is empty. Ghrelin not only aids in stimulating GH release, but it also helps regulate appetite, promote fat loss in muscle tissues and helps in healing damaged tendons. Studies suggest that elevated levels of Ghrelin in the stomach have been shown to have a direct link with fast healing of damaged tissues. This is why GHRP-6 may be a better option for healing than the newer modified version GHRP-2. GHRP-2 works the same as GHRP-6 but the extreme hunger side effect is not as severe.
GHRP-6 is known for being a big appetite stimulator, but it is not the strongest GH releasing peptide in the GHRP family. There are other members of the GHRP family we should briefly look at. This list is in order from strongest to weakest.
- Hexarelin – The strongest in the family known to give the biggest pulse of all. Will create prolactin and cortisol side effects. Desensitization will happen regardless of the dose
- GHRP-2 – Second in the category, however, desensitization is unclear if used beyond saturation dose
- GHRP-6 – Third in the lineup for potency, and when shots are broken up, desensitization does not occur. Slightly creates prolactin and cortisol issues
- Ipamorelin – This mildest in the bunch, does not create prolactin or cortisol and at very large doses was shown to give a large release of GH without desensitization
Increased effect from combining GHRP-6 with a GHRH
While GHRP-6 is capable of inducing large increases in GH production when used alone, a given dose will show markedly more effect what a GHRH (growth hormone releasing hormone) peptide is taken at the same time. Alternately, when combining a GHRH with GHRP-6, only about half or a third as much GHRP-6 is needed to obtain the same increase in GH production.
For this reason, it’s a common choice to combine a GHRH with a GHRP, but excellent results are often obtained without doing so. A preferred choice of GHRH is Mod GRF 1-29 (also known as CJC-1295 without DAC.)
Dosing and Usage
Despite it being third in class as far as strength of GH release, GHRP-6 is still a potent GHRP and can be taken 2-3 times per day. Though there is a slight issue, GHRP-6 has been shown to not be as effective in the presence of elevated blood glucose levels. As a result, I believe the best practice for GHRP-6 dosing is to dose 2 hours after your last meal and 30 minutes before you take in any food, so that no interactions weaken the effect of GHRP-6. Taking this into consideration, GHRP-6 can be taken 2-3 times a day (approximately 3 hours in between injections) for maximum effectiveness with a range of 100mcg-200mcg per dose. Beyond these doses, GHRP-6 was not shown to be any more effective. These saturation points are why you are going to want to break up your administration times throughout the day to allow the receptors to clear.
- 100mcg upon waking
- 100mcg post workout
- 100mcg before bed
GHRP-6 is not sex specific, so the same doses also apply to women as they do men. Like other peptides, GHRP-6 comes as a lyophilized (freeze-dried) powder in the amount of 5mg or less. GHRP-6 must be reconstituted with bacteriostatic water and stored in a cool dry place like your refrigerator. Insulin syringes are the best way to administer the hexapeptide often subcutaneously or even intramuscularly.
Factors decreasing efficacy of GHRP-6
For increasing GH levels, GHRP-6 is less effective in the presence of high blood glucose levels or high somatostatin levels, which result from high IGF-1 levels. For this reason, for best effect GHRP-6 should be taken while blood sugar is relatively low, for example about 30-60 minutes before a meal. GHRP-6 will have reduced effect if GH is being taken by injection, because GH increases IGF-1. Where GH use is limited to no more than about 14 IU per week, simultaneous GHRP-6 use probably still will increase GH somewhat further, but if GH use is greater than this then likely GHRP-6 injections will do little to nothing towards increasing GH levels any further.
Low thyroid levels also decrease efficacy of GHRP-6, and modestly increased thyroid levels, such as with 50-200 mcg/day of T4, or 12.5-50 mcg/day of T3, may improve efficacy. (If T3 is used, dosage should be divided into three doses per day.)
GHRP-6 and gynecomastia
While I doubt that GHRP-6 use is likely to cause gynecomastia (gyno), elevation of prolactin from GHRP-6 use can be problematic for some individuals who already have gyno, including undetected gyno which developed during puberty. Ipamorelin can be a better choice of GHRP for such individuals.
Where to get GHRP-6
You can find GHRP-6 on several peptide supplier websites. These websites can only legally sell the peptides for research purposes. For example:
The expectations from GHRP-6 should fall in line with any other form of HGH, but, of course, to get the very most out of your GHRP-6 it is often synergetically paired with a GHRH like CJC-1295 without DAC. Dramatic results may not happen overnight with any peptides; however, improved sleep and hunger stimulation should be felt immediately. With proper diet and training, users will find changes to physique occur within one month of usage. So, to recap, GHRP-6 is a potent growth hormone releasing peptide, but it’s not the most potent of the GHRP family. It has a strong affinity to cause hunger spikes. Used with GHRH, it allows users to release the maximum amount of stored growth hormone in their body. GHRP-6 may aid in some fat loss, but it’s better know to help with sleeping patterns, increase energy and increase in lean body mass. This is why bodybuilders are drawn to using this hexapeptie. Lastly, GHRP-6 is one of the only peptides that is known to actively increase ghrelin in the stomach.