The following article was written by Albert Wolfgang
Nutrobal (Mk-677) is an orally administrated growth hormone secretagogue originally developed by Reverse Pharmacology. A secretagogue is the term for a substance that chemically signals for the pituitary gland to secrete growth hormone. In other words, Nutrobal could be compared to peptides like GHRP-6 or Ipamorelin, only it doesn’t require any injections nor does it have any side effects like GHRP-6. This GHS (Growth Hormone Secretagogue) was developed in an aim to combat such conditions as muscle wasting, obesity and osteoporosis. It was also targeted towards treatment of elderly hip fracture patients, so there are a myriad of studies done on safety.
How it Works
Growth hormone pulse intensity can be increased through 4 possible mechanisms:
- Increasing GHRH (growth hormone releasing hormone) release
- Amplifying GHRH signaling in somatotrophs of the anterior pituitary gland
- Reducing somatostatin release (somatostatin turns off GH release)
- Inhibiting of somatostatin receptor signaling
Nutrobal (Mk-677) was found to work through all four of these mechanisms. After ingestion, Growth Hormone (GH) was shown to increase dose dependently, at doses starting at 5 milligrams (mgs) a day.
In a study on it’s effects on catabolic states, a once daily oral dose of 25mgs was given to healthy young men subjected to short-term diet-induced nitrogen wasting. After 7 days of this dose, the subjects showed a sustained increase in serum concentration of IGF-1 and Growth Hormone; in addition, the nitrogen wasting was reversed, showing great potential for treatment of conditions involving muscle wasting.
Trials testing the effects of this GHS on fighting obesity showed an increase in lean body mass, but neither total, nor visceral adipose tissue was effected. This study gave subjects 25mgs of Nutrobal per day for 8 weeks. The subjects showed an increase in basal metabolic rate after 2 weeks, and an increase in serum levels of GH, IGF-1 and IGF-1 binding protein-3. Increase in lean body mass was hypothesized to be caused by an increase in calorie deposition into the muscle and appetite decrease as opposed to reducing fat storage directly.
A study done for the treatment of osteoporosis and bone mineral density showed some increase in bone density, so there is a true impact on bone mineral density. This can help with injury recovery during your cycle.
Other possible benefits of Nutrobal are associated with improved sleep, improved complexion, increase in energy levels, increase nitrogen retention, increase strength and an improved sense of well being. In addition, some studies also suggest that an increased immune system response was caused by Nutrobal (Mk-677), meaning it boosts the immune system to a degree.
How can it help you?
Elevated growth hormone has literally endless list of benefits to the human body, why do you think everyone tries to get their hands on HGH? That’s why Nutrobal (Mk-677) is so effective, it increases Growth Hormone and IGF-1 levels.
As the studies show, Nutrobal can be used for a number of reasons from growing muscle mass, to getting shredded. It does not compete with the levels of growth hormone one can get from exogenously administered HGH, so you can use it with hgh cycles. In fact, by using nutrobal, you can easily get amazing increases of your own natural growth hormone pulses without having to deal with annoying and painful daily HGH injections. It’s like using HGH without having to inject daily.
In a multitude of studies, Nutrobal (Mk-677) increased IGF-1 levels by between 39-89%. To give you an idea of what IGF-1 does, here are some IGF-1 benefits:
- Increased Fat Oxidation (fat loss)
- Increased Muscle gains (lean mass)
- Tightening up loose skin
- Healing old injuries
- Healing Bones, Tendons and Ligaments
In fact, many users report growing up to 6 lbs of lean muscle mass in 8 weeks of IGF-1 only cycles. That’s an amazing result, but injecting IGF-1 daily is painful, costly and frustrating. Now, there is an oral-only alternative.
Results have been shown from doses between 5-25mgs a day, dose dependent results should be expected. Higher doses, over 50mgs, have been reported by some, but I don’t see the need to overdo it.
Some of the usual side effects that go with elevated GH levels such as numb hands, some lethargy, as well as slight increased appetite have been reported with the use of Mk-677.
Interestingly, during prolonged administration both IGF-1 and GH were increased with no increase in cortisol.
Some anecdotal evidence suggested there was a temporary small increase in prolactin when beginning administration, so individuals who are very prone to prolactin side effect may want to incorporate a short schedule of HCGenerate ES to prevent problems. I want to stress, this is only an issue for guys who are extremely prone to prolactin sides, which is usually 1% of users. How do you know if you’re prone to prolactin sides? If you get gynecomastia from taking trenbolone, you’re prone to prolactin sides.
Nutrobal (Mk-677) was found to be very safe and, in fact, showed to reduce tumors in mice, which was hypothesized to be from an increased immune system response.
Noticed enhanced recovery, muscle fullness, better skin, and increased hunger. The first week or so the hunger cravings were intense but this thankfully subsided for the most part afterwards. Hunger/food intake still remaining above baseline though. I think I will continue to take this stuff indefinitely in order to keep my GH serum and IGF1 levels at the top end/slightly over reference range for quality of life purposes.
Started 25mg two months ago. Plan to stay on as long as I can afford it. Immediate effects were mostly side effects. I gained 10lbs of water weight my first week on and my knees and ankles hurt to the point I couldn’t walk for a while in the morning. I would strongly suggest using a diuretic as this is both painful and potentially bad for your health.
First week the sleep was what I thought was bad. I was waking up an hour before what I normally did but throughout the week I realized I felt more energized and rejuvenated than before. This continues to today, less sleep is more restful. Combine with melatonin and you can fall asleep fast and hard and only need a little sleep a night.
Hunger was to me less an actual hunger pain (though that happened) and more the state of never being able to eat enough food to feel satisfied. And I tried. I was doing intuitive dieting pretty successfully and decided to keep doing it. I ate shitty foods at around a 1000-1500 surplus and after losing the water weight had gained 6-8lbs in a month but appeared to be more lean. This effect tapers off though but so does the hunger leading me to believe the spike in growth hormone needs a supporting amount of calories as new growth is occurring whatever that is. I think mainly bone density increases which is a high cost of calories. But I won’t pretend to know. Anyways suggestion would be if you feel like you are too hungry take ephedrine.
Recovery seemed to increase though I will say I was running some peptides for an injury and attribute the recovery mostly to that. In terms of muscle growth it seemed to me mk-677 would increase how much you could build in a given time, good stack to aas, especially if you have trouble eating.
I’m finally getting to the point of those more obscured effects. But I will say I used this partially with the hope some stretch marks would fade and they have visibly faded, beyond what my other measures would have made them. My skin appears healthier in general. Hair also appears healthier(may be my imagination but it is more colorful).
Use it since 2 weeks on 30mg ED with a Test/Deca Bulk.
Benefits: – way better sleep – also feel more rested after sleep and therefore I have more energy during the day – vivid dreams – little increase in appetitte – better joints – better Skin & hair – more vivid and better looking eyes.
Sides: – gained few pounds of water – puffy face – extreme pumps (especially forearms during the day)
I love it and will use it for at least another 30 weeks of my bulk.
I’m on it and planning to stay on for around 6 months. Currently dosing 25mg a day for 6 days a week. Appetite is good, sleep is amazing and my hair has gotten much more healthy looking and feeling. I get quite bloated on it though so when I start my next blast in a few weeks I’m scaling it back to 15mg. It hasn’t done as much for my skin as I’d hoped but perhaps the longer I run it the better it will be. Apparently it’s a great compound to run prior to and during PCT.
I’ve been on and off this for months. The biggest unexpected thing I noticed is that I am more prone to anxiety on the compound, and long-acting ghrelin mimetics are discussed over at Datbtrue.
Which cites primarily this study: A ghrelin–growth hormone axis drives stress-induced vulnerability to enhanced fear(2013)
So users with depression, take note that this may be a problematic compound.
That said, I love all the other effects. Incredible for hunger boosts, easy to administer, affordable, and gets you all the GH spikes you need.
I’ve ran MK-677 a few times. I haven’t tried anything else that’s upped my hunger long term to any extent. Not weed, ghrp6 or any thing I can think of (up until I tried anamorelin recently, that wins). But within the first couple days I’d notice some water retention. Pretty variable depending in the person from what I’ve seen. Some hold a lot, some hold a little, even if it’s same batches from the same company.
After about 3 weeks that bloat just kinda started feeling/looking like fullness. Strength was up, sleep quality was awesome, some days I’d be a bit tired during the day too and my forearms and arms really blew up. I could recover quicker from heavy sessions in the gym. After dropping the MK-677 and losing any bloat I noticed I barely put on much fat even though I was basically dreamer bulking. I can’t run mk677 on a cut or maintenance really. Too tough. I’ve ran it with test/deca and test/tren as well as various orals.
I’ve ran it at both 25mg and 50mg. There were better effects at 50mg but not sure if it’s worth the cost. My father has also been running this since July.